Call for Proposals for Alternative Testing Strategies FP7-HEALTH-2010-Alternative-Testing Closed!

Objectives

The full replacement of animals in safety testing is a very challenging long-term target in the implementation of the Three Rs principle (Replacement, Reduction, Refinement). Relevant legislation, regulations and directives require urgently a phasing out of animal tests thus putting a high pressure on research, validation and regulatory acceptance.

The present call focuses on the construction of a solid foundation of this long term task. It reflects the research strategy for the next years aimed at the development of 'human safety assessment strategies'.

The research plan for the first phase will include the specific building blocks: development and use of functional human-based target cells, identification of intermediate biomarkers and endpoints with clinical relevance, construction of advanced organ-simulating devices, the development of biological models with emphasis on systems biology, Quantitative Structure Activity Relationships (QSARs), Physiologically Based Pharmacokinetic Modeling (PBPK), and Threshold of Toxicological Concern (TTC), and integrated data analysis and servicing.

Applicants are strongly encouraged to examine how new scientific disciplines could be included in project proposals in order to develop truly novel approaches towards human safety assessment. R&D results should be disseminated broadly to the public domain for the benefit of science and society as a whole. Where appropriate, active participation of small and medium-sized enterprises (SMEs) is strongly recommended in order to increase the impact of the research proposed.

In adition to our useful documents section, further informations, as well as relevant documents for FP7-HEALTH-2010-Alternative-Testing Call for Proposals can be found at FP7 Cordis website.

Actions

HEALTH.2010.4.2.9-1: Optimisation of current methodologies and development of novel methods to achieve functional differentiation of human-based target cells in vitro

  • Refinement of cell culture systems for long-term toxicity testing
  • Exploitation of emerging mechanistically-driven methods controlling cellular differentiation

HEALTH.2010.4.2.9-2: Exploitation of organ-simulating cellular devices as alternatives  for long-term toxicity testing

  • Integration of target and metabolising cells to simulate multi-organ-related toxicity in vitro
  • Utilisation of scaffolds and microstructures to optimise the cellular microenvironment
  • Development of novel cellular barrier models relevant to systemic exposure
  • Optimisation of microsensors to monitor tissue responses in organ-simulating devices

HEALTH.2010.4.2.9-3: Establishment of endpoints and intermediate markers in human-based target cells with relevance for repeated dose systemic toxicity testing

  • Functional parameters as predictive signals of human long-term toxicity
  • Establishment of “-omics”-based markers as predictive signals of human long-term toxicity Integration of markers for enhancement of human long-term predictive capacity

HEALTH.2010.4.2.9-4: Computational modelling and estimation techniques.

  • Threshold of toxicological concern approach for the safety assessment of cosmetic ingredients
  • Innovative computational chemistry approaches in the safety assessment of cosmetic ingredients
  • Predicting the dose at the target level upon long-term exposure
  • PBPK modelling in the safety assessment of cosmetic ingredients

HEALTH.2010.4.2.9-5: Systems biology for the development of predictive causal computer models

  • Identification and analysis of pathways relevant to long-term toxicity by genetic tools
  • Use of “-omics”- based techniques to identify mechanistic pathways involved in long-term toxicity effects
  • Development of causal predictive computer models for long-term toxicity effects

HEALTH.2010.4.2.9-6: Integrated data analysis and servicing.

  • Establishment of a dedicated web-based 'data warehouse'
  • Establishment of a database of selected model compounds
  • Establishment of a repository for the selected model compounds
  • Setting up a cell and tissue bank for in vitro toxicity testing

HEALTH.2010.4.2.9-7: Coordination action

  • Tailor-made progress monitoring and reporting towards the major stakeholder groups
  • Organisation of meetings and workshops
  • Facilitating information exchange among members of the participating institutions

European community funding

The Community provisional funding available for the call for proposals is:

  • 25,00 Million EUR (Global Budget)

All the important deadlines

  • 03 February 2010 - 9 years ago (Deadline for the presentation of proposals)

Further information about the call

Useful documents

  • Work Programme 2010 - Health (Work programme)
  • Call for Alternative Testing Strategies (Legal base)

Organisations eligible to participate

Opened to the following bodies or institutes with legal status established in the covered areas:

  • Any legal organisation

Covered areas

Bodies or institutes must have their registered legal seat in one of the countries taking part in the Programme which are:

  • European Union (EU)

Directorate-Generale responsible

Directorate-General for Research

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